Schwarz R, Göretzlehner G, Wolf E, Haude W
Zentralbl Gynakol. 1984;106(15):1077-83.
In 100 healthy primigravidae the concentration of serum uric acid was examined in a prospective longitudinal study between the 12th and 40th gestational week. Serum uric acid increased continuously and was elevated significantly in 9 women who developed toxaemia of late pregnancy at the 16th, 32nd, and 36th week of pregnancy. If serum concentration are higher than 220 mumol/l or 241 mumol/l in the 32nd gestational week they were considered for a increased risk of developing a hypertensive complication. Sensitivity, specificity and the predictive value of a "positive test" were low in the 16th (22 or 20%) and 32nd (16 or 17%) week of pregnancy. The predictive value of a "negative test" was relative high in the 16th and 32nd week with 93 or 90% respectively 95 or 92%.
在一项前瞻性纵向研究中，对100名健康初产妇在妊娠第12周到第40周期间的血清尿酸浓度进行了检测。血清尿酸持续升高，9名在妊娠第16周、32周和36周发生晚期妊娠中毒症的女性血清尿酸显著升高。如果在妊娠第32周时血清浓度高于220μmol/l或241μmol/l，则被认为发生高血压并发症的风险增加。在妊娠第16周（22%或20%）和第32周（16%或17%）时，“阳性检测”的敏感性、特异性和预测值较低。在第16周和第32周时，“阴性检测”的预测值相对较高，分别为93%或90%、95%或92%。
