Müller U, Link M, Bellée H, Mühlbach F
Zentralbl Gynakol. 1983;105(10):629-34.
A correlation between gestosis and increase of serum uric acid level has been known for a longtime. From the 6th month of pregnancy we found significantly increased values in all hypertensive pregnant women. In the 7th and 8th month of pregnancy there was a high significant deviation in gestoses second degree (classification of the organisation gestosis). In the two last months of pregnancy all gestoses deviated high significantly from the uric acid level in serum of the normal collective. There is a correlation between pathologically increased mean uric acid values in the 9th and 10th lunar month and increased systolic and diastolic blood pressure values. The uric acid level in pregnant women with gestosis, whose illness or its consequences led to cesarean section, is significantly higher than in patients with normal delivery. In accordance with literature we could not find a limit above the fetus dies. In our opinion determination of plasma uric acid in late pregnant hypertensive women is one additional parameter calculating both maternal prognosis and fetal risk.
妊娠期高血压疾病与血清尿酸水平升高之间的相关性早已为人所知。从妊娠第6个月起,我们发现所有高血压孕妇的尿酸值均显著升高。在妊娠第7和第8个月,二度妊娠期高血压疾病(妊娠期高血压疾病的组织分类)存在高度显著偏差。在妊娠的最后两个月,所有妊娠期高血压疾病患者的尿酸水平与正常人群血清中的尿酸水平相比均有高度显著偏差。妊娠第9和第10个农历月病理性升高的平均尿酸值与收缩压和舒张压升高值之间存在相关性。因妊娠期高血压疾病及其后果导致剖宫产的孕妇,其尿酸水平显著高于顺产患者。根据文献,我们未发现胎儿死亡的尿酸上限。我们认为,测定晚期妊娠高血压妇女的血浆尿酸是评估母亲预后和胎儿风险的又一参数。