Driessen J J, Gielen M J, Nijhuis G M
Acta Anaesthesiol Belg. 1984 Jun;35(2):145-54.
The clinical effects of epidural anesthesia with bupivacaine 0.75% for elective caesarean section were investigated in 20 healthy pregnant women. The mean total dose of bupivacaine which offers sufficient sensory and motor block, provided the epidural catheter is properly placed, was 137.5 mg. Maternal hypotension occurred in 4 patients in spite of prehydratation and left uterine displacement. No maternal systemic toxicity or local neurotoxicity was found. The results of the Apgar scoring and the neonatal acid-base studies showed that there is no clinically important neonatal depression with this technique.
在20名健康孕妇中研究了0.75%布比卡因用于择期剖宫产的硬膜外麻醉临床效果。在硬膜外导管放置正确的情况下，产生足够感觉和运动阻滞的布比卡因平均总剂量为137.5毫克。尽管进行了预补液和子宫左倾，但仍有4例产妇发生低血压。未发现产妇全身毒性或局部神经毒性。阿氏评分和新生儿酸碱研究结果表明，该技术不会引起具有临床意义的新生儿抑制。
