毒扁豆碱、对氧磷和梭曼对脑γ-氨基丁酸水平及代谢的影响。

Effects of physostigmine, paraoxon and soman on brain GABA level and metabolism.

作者信息

Coudray-Lucas C, Prioux-Guyonneau M, Sentenac H, Cohen Y, Wepierre J

出版信息

Acta Pharmacol Toxicol (Copenh). 1984 Aug;55(2):153-7. doi: 10.1111/j.1600-0773.1984.tb01978.x.

DOI:10.1111/j.1600-0773.1984.tb01978.x

Abstract

The effects of sublethal doses of physostigmine, paraoxon and soman on GABA levels and metabolism were studied in small rat brain areas (hypothalamus, striatum, cerebellum, rest of the brain). Physostigmine induced a significant decrease in striatal GABA level and a reduction of synthesis index in the rest of the brain while organophosphates have little or no effect on GABA level and metabolism. This work provides new data about the physostigmine effect on brain GABA which could be related to the action of the anticholinesterase agents on other non-cholinergic neurotransmitters.

摘要

研究了亚致死剂量的毒扁豆碱、对氧磷和梭曼对大鼠脑小区域（下丘脑、纹状体、小脑、脑的其他部分）γ-氨基丁酸（GABA）水平及代谢的影响。毒扁豆碱可使纹状体GABA水平显著降低，并使脑的其他部分的合成指数降低，而有机磷酸酯对GABA水平及代谢几乎没有影响。这项研究提供了有关毒扁豆碱对脑GABA作用的新数据，这可能与抗胆碱酯酶药物对其他非胆碱能神经递质的作用有关。