亚诺玛米印第安人中变异白蛋白与胆红素的结合
Bilirubin binding by variant albumins in Yanomama Indians.
作者信息
Lorey F W, Ahlfors C E, Smith D G, Neel J V
出版信息
Am J Hum Genet. 1984 Sep;36(5):1112-20.
Abstract
Sera of Yanomama Indians homozygous for the common albumin allele exhibited greater total effective-binding capacities for bilirubin than did sera of individuals homozygous for the Yan-2 albumin variant in the in vitro experiments described herein. Total effective binding capacities of heterozygous samples were close to those of homozygotes for AlA. Individuals homozygous for Yan-2 might experience a higher risk of bilirubin toxicity and related disorders during the neonatal period. Further studies of binding and displacement of bilirubin by competitors, such as dietary or medicinal coumarins, might help explain the existence of these polymorphisms and the significance of phenotypic differences in binding to bilirubin.
摘要
在本文所述的体外实验中，对于常见白蛋白等位基因纯合的雅诺马马印第安人的血清，其对胆红素的总有效结合能力高于对Yan - 2白蛋白变体纯合的个体的血清。杂合样本的总有效结合能力接近AlA纯合子的总有效结合能力。对于Yan - 2纯合的个体在新生儿期可能面临更高的胆红素毒性及相关病症风险。进一步研究胆红素与诸如膳食或药用香豆素等竞争者的结合及置换情况，可能有助于解释这些多态性的存在以及与胆红素结合的表型差异的意义。
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本文引用的文献
1
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Am J Obstet Gynecol. 1950 May;59(5):1153-9. doi: 10.1016/s0002-9378(16)39185-2.
2
Binding of bilirubin to human serum albumin - determination of the dissociation constants.胆红素与人血清白蛋白的结合——解离常数的测定
FEBS Lett. 1969 Oct 21;5(2):112-114. doi: 10.1016/0014-5793(69)80307-8.
3
Analysis of fluorescence quenching data by the method of Levine.用莱文方法分析荧光猝灭数据。
Clin Chem. 1980 Dec;26(13):1869-71.
4
Scatchard plot: common misinterpretation of binding experiments.斯卡查德图：结合实验中常见的错误解读
Anal Biochem. 1980 Mar 1;102(2):318-20. doi: 10.1016/0003-2697(80)90160-8.
5
Competitive interaction of biliverdin and bilirubin only at the primary bilirubin binding site on human albumin.仅在人白蛋白上的主要胆红素结合位点处，胆绿素与胆红素存在竞争性相互作用。
Anal Biochem. 1981 Jan 15;110(2):295-307. doi: 10.1016/0003-2697(81)90195-0.
6
7
8
Serum albumin polymorphism in Indians of the southwestern United States.美国西南部印第安人的血清白蛋白多态性
Nature. 1968 Oct 12;220(5163):175-6. doi: 10.1038/220175a0.
9
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Clin Chim Acta. 1971 Jan;31(1):87-96. doi: 10.1016/0009-8981(71)90365-2.
10
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