Grunbaum D, Wexler M, Antos M, Gascon-Barré M, Goltzman D
Am J Physiol. 1984 Oct;247(4 Pt 1):E442-8. doi: 10.1152/ajpendo.1984.247.4.E442.
Bioactive parathyroid hormone and hormonal actions were monitored as hyperparathyroidism evolved in a model of progressive canine renal failure. Circulating levels of bioactive and immunoreactive parathyroid hormone rose as renal insufficiency worsened, but elevations, especially in bioactivity, were most marked in the final stage of uremia. By gel filtration analysis, the major circulating bioactive moiety was similar to the major glandular form of parathyroid hormone, although a smaller-molecular-weight entity was seen in the final stage of renal failure. Renal phosphate threshold fell, urinary hydroxyproline corrected for glomerular filtration rose, and plasma 1,25-dihydroxyvitamin D fell but remained detectable, as renal function deteriorated. The results demonstrate a progressive rise in bioactive parathyroid hormone, show the appearance of a small-molecular-weight bioactive entity in severe renal disease, and correlate effects of the rising bioactive parathyroid hormone with changes in renal phosphate handling and with skeletal resorption.
在犬类进行性肾衰竭模型中，随着甲状旁腺功能亢进的发展，对生物活性甲状旁腺激素及其激素作用进行了监测。随着肾功能不全的加重，循环中生物活性和免疫反应性甲状旁腺激素水平升高，但升高情况，尤其是生物活性的升高，在尿毒症的最后阶段最为明显。通过凝胶过滤分析，主要的循环生物活性部分与甲状旁腺激素的主要腺体形式相似，尽管在肾衰竭的最后阶段出现了一种分子量较小的实体。随着肾功能恶化，肾磷阈值下降，经肾小球滤过校正的尿羟脯氨酸升高，血浆1,25-二羟维生素D下降但仍可检测到。结果表明生物活性甲状旁腺激素逐渐升高，显示出在严重肾脏疾病中出现了一种小分子生物活性实体，并将生物活性甲状旁腺激素升高的影响与肾脏磷处理的变化以及骨骼吸收相关联。
