Stella A, Golin R, Busnardo I, Zanchetti A
Am J Physiol. 1984 Oct;247(4 Pt 2):H576-83. doi: 10.1152/ajpheart.1984.247.4.H576.
In anesthetized cats (n = 9) renal afferent fibers were electrically stimulated for 11 min, and the response of the contralateral innervated kidney was compared with that of the ipsilateral denervated one. Before stimulation, renal blood flow, glomerular filtration rate, and water and sodium excretions were significantly lower in the innervated kidney than in the denervated one. Afferent renal nerve stimulation augmented arterial pressure and also increased sodium and water excretions from both kidneys without concomitant changes in glomerular filtration rates and renal blood flows. Absolute and percent changes in sodium and water excretions from the innervated kidney were similar to those observed in the denervated one. The same results were obtained in cats (n = 4) which underwent bilateral adrenalectomy to avoid the effect of circulating catecholamines. In another group of cats (n = 5), the increase in renal perfusion pressure due to the stimulation was prevented by an aortic snare: this resulted in a slight but equal decrease of all variables in both kidneys. These experiments do not show a reflex control of renal function from renal afferents.
在麻醉猫（n = 9）中，对肾传入纤维进行11分钟的电刺激，并将对侧有神经支配的肾脏的反应与同侧去神经支配的肾脏的反应进行比较。刺激前，有神经支配的肾脏的肾血流量、肾小球滤过率以及水和钠排泄量显著低于去神经支配的肾脏。肾传入神经刺激会升高动脉血压，同时也会增加双侧肾脏的钠和水排泄量，而肾小球滤过率和肾血流量没有相应变化。有神经支配的肾脏钠和水排泄量的绝对变化和百分比变化与去神经支配的肾脏中观察到的相似。在进行双侧肾上腺切除术以避免循环儿茶酚胺影响的猫（n = 4）中也得到了相同的结果。在另一组猫（n = 5）中，通过主动脉圈套器阻止了由于刺激导致的肾灌注压升高：这导致双侧肾脏所有变量都出现轻微但相等的下降。这些实验未显示肾传入神经对肾功能的反射性控制。
