Clemmons R M, Meyer D J, Sundlof S F, Rappaport J J, Fossler M E, Hubbell J, Dorsey-Lee M R
Am J Vet Res. 1984 Oct;45(10):2167-9.
Dogs exposed to topical organophosphate (fenthion) developed decreased plasma and muscle cholinesterase activities. After 2 doses were applied (1 week between doses), plasma concentrations declined 80% and muscle cholinesterase activity was reduced by 56%. Decremental responses to repetitive nerve stimulation developed after fenthion administration. Diphenhydramine, but not placebo, corrected the electrical abnormalities caused by organophosphate application, but without altering plasma or muscle cholinesterase activity. Control dogs housed in the same kennel demonstrated a slight decrease (18%) of plasma cholinesterase, which indicates that there may be potential cross contamination. Diphenydramine may be effective in treating organophosphate-induced neuromuscular weakness which is refractory to other forms of therapy.
接触局部用有机磷酸酯（倍硫磷）的犬只血浆和肌肉胆碱酯酶活性降低。给予两剂药物（两剂之间间隔1周）后，血浆浓度下降80%，肌肉胆碱酯酶活性降低56%。倍硫磷给药后出现对重复神经刺激的递减反应。苯海拉明而非安慰剂纠正了有机磷酸酯应用所致的电异常，但未改变血浆或肌肉胆碱酯酶活性。饲养在同一犬舍的对照犬只血浆胆碱酯酶略有下降（18%），这表明可能存在潜在的交叉污染。苯海拉明可能有效治疗对其他治疗形式无效的有机磷酸酯诱导的神经肌肉无力。
