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薄层光密度法对水杨酸及其代谢物的定量测定

Quantitative estimation of salicylic acid and its metabolites by thin-layer densitometry.

作者信息

Chrastil J, Wilson J T

出版信息

J Chromatogr. 1978 May 11;152(1):183-9. doi: 10.1016/s0021-9673(00)85348-0.

DOI:10.1016/s0021-9673(00)85348-0
PMID:649744
Abstract

A rapid thin-layer densitometric method for the quantitative determination of salicylic acid and its metabolites in urine or plasma is described. The method is specific and very sensitive. Nanogram quantities of salicylic acid and its metabolites, both free and conjugated, may be estimated. Known metabolites, as well as the newly described gentisuric acid, were estimated quantitatively in urine from a patient treated with aspirin.

摘要

本文描述了一种用于定量测定尿液或血浆中水杨酸及其代谢物的快速薄层密度测定法。该方法具有特异性且非常灵敏。可估算出纳克量的游离及结合形式的水杨酸及其代谢物。对一名服用阿司匹林的患者的尿液中的已知代谢物以及新描述的龙胆尿酸进行了定量估算。

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