Mendak S H, Jensik R J, Haklin M F, Roseman D L
Ann Thorac Surg. 1984 Nov;38(5):488-93. doi: 10.1016/s0003-4975(10)64190-2.
A new type of tracheal prosthesis was studied. It consists of a rigid, porous cylinder of titanium fiber metal coated with a polymer that provides an initial air seal and then is absorbed to permit subsequent fibrous tissue ingrowth and reepithelialization. Fifteen such cylinders measuring 50 mm by 26 mm were coated with one of the following polymers: polycaprolactone 700 (3 coated internally and 3 externally); a copolymer of 75% poly-L-lactic acid and 25% polyglycolic acid (3 coated internally and 3 externally); and polyglactin 910 (3 coated externally). Fifteen kennel-conditioned mongrel dogs, each randomly assigned to one of these five groups, underwent implantation of the prosthesis through a right thoracotomy into a 5-cm defect in the distal intrathoracic trachea. There were no immediate postoperative deaths, and no instances of major air leak from the prosthesis. One animal died after two weeks secondary to a lower respiratory tract infection. Bronchoscopic evaluation revealed varying degrees of tissue ingrowth into the prostheses, with no evidence of infection or distal accumulation of secretions. Histological evaluation showed superior tissue ingrowth and reepithelialization with internally coated prostheses; two out of three polymers gave good results.
研究了一种新型气管假体。它由一个刚性的、多孔的钛纤维金属圆柱体组成，表面涂有一层聚合物，该聚合物提供初始气密封，然后被吸收以允许随后的纤维组织向内生长和再上皮化。15个尺寸为50毫米×26毫米的这种圆柱体分别涂有以下聚合物之一：聚己内酯700（3个内部涂层和3个外部涂层）；75%聚-L-乳酸和25%聚乙醇酸的共聚物（3个内部涂层和3个外部涂层）；以及聚乙交酯910（3个外部涂层）。15只经犬舍饲养的杂种犬，每只随机分配到这五组中的一组，通过右胸切开术将假体植入胸段气管远端5厘米的缺损处。术后无即刻死亡病例，假体也无严重漏气情况。一只动物在两周后因下呼吸道感染死亡。支气管镜检查显示假体有不同程度的组织向内生长，无感染或分泌物远端积聚的迹象。组织学评估显示内部涂层假体的组织向内生长和再上皮化效果更好；三种聚合物中有两种效果良好。
