Locke R, Hauser C J, Shoemaker W C
Arch Surg. 1984 Nov;119(11):1252-6. doi: 10.1001/archsurg.1984.01390230024005.
Tissue depends on perfusion, but tissue oxygenation measurements have been impractical. To develop a method for the clinical evaluation of bowel viability, we studied PO2 on the bowel surface (PSO2). The PSO2 was assessed on the stomach and intestine of 11 dogs. Normal small-bowel PSO2 was 44 +/- 11 mm Hg (mean +/- SD). When bowel vasculature was interrupted PSO2 rapidly decreased. Reductions in PSO2 were related to the degree of ischemia produced. Anastomoses were performed on partially devascularized bowel to determine anastomotic viability at various levels of PSO2. The PSO2 measured just prior to anastomosis predicted viability of the anastomoses at 48 hours. Anastomoses below 30% of predevascularization PSO2 necrosed. Between 30% and 50%, one third of anastomoses leaked. At PSO2 values above 50% of initial normal value all anastomoses healed. Surface oximetry allows accurate intraoperative assessment of bowel perfusion.
组织依赖于灌注，但组织氧合测量一直不切实际。为了开发一种临床评估肠活力的方法，我们研究了肠表面的氧分压（PSO2）。对11只狗的胃和肠进行了PSO2评估。正常小肠PSO2为44±11毫米汞柱（平均值±标准差）。当肠血管被阻断时，PSO2迅速下降。PSO2的降低与所产生的缺血程度相关。对部分去血管化的肠进行吻合，以确定在不同PSO2水平下吻合口的活力。吻合术前测得的PSO2可预测48小时时吻合口的活力。低于去血管化前PSO2 30%的吻合口坏死。在30%至50%之间，三分之一的吻合口渗漏。当PSO2值高于初始正常值的50%时，所有吻合口均愈合。表面血氧测定法可在术中准确评估肠灌注。
