Kram H B, Shoemaker W C, Hino S T, Harley D P
Arch Surg. 1984 Nov;119(11):1309-11. doi: 10.1001/archsurg.1984.01390230075018.
Fibrin sealant (FS) is a biologic adhesive containing highly concentrated human fibrinogen that is effective in the face-to-face sealing of tissues, and in establishing hemostasis. We evaluated FS in 32 experimentally produced splenic injuries in six adult mongrel dogs. Complete hemostasis was achieved in all animals prior to closure. The dogs were reexplored postoperatively at intervals varying from four hours to six weeks (mean +/- SD, 21 +/- 20 days). When the dogs were killed, there was no gross evidence of splenic disruption or recurrent bleeding; all of the spleens had developed well-healed capsules. Histologic examination demonstrated a regenerated fibrous capsule extending over the superficial injuries as well as into the deep injuries, without significant inflammatory response. We conclude the following: that FS provides adequate hemostatic control of superficial and deep splenic injuries, FS has good systemic and local compatibility, it can be applied to bleeding parenchymal wounds, it reduces the need for parenchymal sutures that may be traumatic, and it promotes splenic wound healing.
纤维蛋白密封剂（FS）是一种生物粘合剂，含有高浓度的人纤维蛋白原，可有效实现组织的面对面密封并实现止血。我们在6只成年杂种犬的32处实验性脾损伤中评估了FS。在闭合前所有动物均实现了完全止血。术后每隔4小时至6周（平均±标准差，21±20天）对犬进行再次探查。处死犬时，没有肉眼可见的脾破裂或复发出血的证据；所有脾脏均形成了愈合良好的包膜。组织学检查显示，再生的纤维包膜延伸至浅表损伤以及深部损伤处，无明显炎症反应。我们得出以下结论：FS能对浅表和深部脾损伤提供充分的止血控制，FS具有良好的全身和局部相容性，可应用于出血的实质伤口，减少了可能造成创伤的实质缝合需求，并促进脾伤口愈合。
