Belcon M C, Haynes R B, Tugwell P
Arthritis Rheum. 1984 Nov;27(11):1227-33. doi: 10.1002/art.1780271104.
Nineteen studies of treatment compliance in rheumatoid arthritis (RA) patients have been critically appraised to assess the magnitude and determinants of noncompliance in this population. Deficiencies in study methodology undermined the possibility of firm conclusions on the influence of various factors on compliance in RA populations. Nevertheless, it is apparent that noncompliance with treatments for RA is a major problem that hitherto has not been widely considered. Compliance with prescribed drug regimens varied from 16% to 84% among these studies. With physiotherapy regimens, compliance rates varied from 39% to 65%, while for splint-usage, rates varied from 25% to 65%. No consistent correlation has been demonstrated between compliance and age, sex, treatment side effects, disease severity, or drug dose frequency. Gaps in our present day knowledge have been detailed and the need for further research is outlined.
针对类风湿性关节炎（RA）患者治疗依从性的19项研究已得到严格评估，以评估该人群中不依从的程度及决定因素。研究方法的缺陷削弱了就各种因素对RA人群依从性的影响得出确凿结论的可能性。尽管如此，很明显，不依从RA治疗是一个迄今为止尚未得到广泛关注的主要问题。在这些研究中，对规定药物治疗方案的依从率在16%至84%之间。对于物理治疗方案，依从率在39%至65%之间，而对于夹板使用，依从率在25%至65%之间。尚未证明依从性与年龄、性别、治疗副作用、疾病严重程度或药物给药频率之间存在一致的相关性。本文详述了我们目前知识上的空白，并概述了进一步研究的必要性。
