Brus H L, van de Laar M A, Taal E, Rasker J J, Wiegman O
Department of Rheumatology, Medisch Spectrum Twente, The Netherlands.
Ann Rheum Dis. 1998 Mar;57(3):146-51. doi: 10.1136/ard.57.3.146.
To determine the effects of patient education on compliance and on health in patients with active, recent onset rheumatoid arthritis (RA).
A randomised, controlled, assessor blinded, one year trial. The experimental group followed an education programme. All patients started on sulphasalazine therapy. Compliance with sulphasalazine was measured by pill counting. Compliance rates with regimens of physical exercise, endurance activities, and energy conservation were measured by questionnaires. Compliance with prescriptions of joint protection was scored using a test for joint protection performance. Health was measured by a Disease Activity Score (function of erythrocyte sedimentation rate, Ritchie score, and number of swollen joints), C reactive protein, Dutch-AIMS scores, and M-HAQ scores, range of motion of shoulder, elbow, and knee joints. Parameters were scored at baseline and after three, six, and 12 months.
Sixty of 65 patients gave informed consent, five of them withdrew from follow up. Compliance with sulphasalazine exceeded 80% with no differences between groups. Compliance with physical exercise (at three months), energy conservation (at three and at 12 months), and joint protection (at three months) improved significantly more in the experimental group. The improvements of health were not different in the groups.
Compliance with sulphasalazine among patients with active, recent onset RA is high, whether formal patient education is followed or not. Compliance with physical exercise, energy conservation, and joint protection was increased by patient education. Formal patient education did not improve health status.
确定患者教育对近期发病的活动性类风湿关节炎(RA)患者的依从性和健康状况的影响。
一项随机、对照、评估者盲法的一年期试验。实验组遵循一项教育计划。所有患者均开始使用柳氮磺胺吡啶治疗。通过清点药片来测量对柳氮磺胺吡啶的依从性。通过问卷调查来测量对体育锻炼、耐力活动和节能方案的依从率。使用关节保护性能测试对关节保护处方的依从性进行评分。通过疾病活动评分(红细胞沉降率、里奇评分和关节肿胀数量的函数)、C反应蛋白、荷兰-关节炎影响测量量表(Dutch-AIMS)评分和健康评估问卷(M-HAQ)评分、肩关节、肘关节和膝关节的活动范围来衡量健康状况。在基线以及3个月、6个月和12个月后对各项参数进行评分。
65名患者中有60名给予了知情同意,其中5名退出了随访。两组对柳氮磺胺吡啶的依从性均超过80%,无差异。实验组在体育锻炼(3个月时)、节能(3个月和12个月时)和关节保护(3个月时)方面的依从性改善更为显著。两组的健康改善情况没有差异。
无论是否接受正规的患者教育,近期发病的活动性RA患者对柳氮磺胺吡啶的依从性都很高。患者教育提高了对体育锻炼、节能和关节保护的依从性。正规的患者教育并未改善健康状况。