Imaizumi T, Takeshita A, Ashihara T, Nakamura M, Tsuji S, Shibazaki H
Br Heart J. 1984 Nov;52(5):581-4. doi: 10.1136/hrt.52.5.581.
Since indomethacin may be effective in the treatment of orthostatic hypotension, the ability of this drug to increase reflex vasoconstriction was studied in six patients with orthostatic hypotension and in five normal subjects. Reflex forearm vasoconstriction during lower body negative pressure at 20-40 mm Hg was measured before and after indomethacin 50 mg by mouth. In patients with orthostatic hypotension and central nervous system involvement indomethacin increased recumbent blood pressure, resting forearm vascular resistance, and reflex forearm vasoconstriction during lower body negative pressure. The fall in blood pressure with lower body negative pressure was not significantly inhibited by indomethacin, but mean blood pressure during lower body negative pressure was higher after than before indomethacin. Indomethacin did not alter these responses in normal subjects. The increase in reflex vasoconstriction with indomethacin may contribute to its therapeutic effects in the treatment of orthostatic hypotension.
由于吲哚美辛可能对体位性低血压的治疗有效，因此在6例体位性低血压患者和5名正常受试者中研究了该药增强反射性血管收缩的能力。口服50毫克吲哚美辛前后，测量了20-40毫米汞柱下体负压期间的反射性前臂血管收缩情况。在伴有体位性低血压和中枢神经系统受累的患者中，吲哚美辛可提高卧位血压、静息前臂血管阻力以及下体负压期间的反射性前臂血管收缩。吲哚美辛并未显著抑制下体负压引起的血压下降，但下体负压期间的平均血压在服用吲哚美辛后高于用药前。吲哚美辛对正常受试者的这些反应没有影响。吲哚美辛引起的反射性血管收缩增强可能有助于其在体位性低血压治疗中的疗效。
