吲哚美辛对帕金森病姿势性低血压的影响。
Effects of indomethacin on postural hypotension in Parkinsonism.
作者信息
Abate G, Polimeni R M, Cuccurullo F, Puddu P, Lenzi S
出版信息
Br Med J. 1979 Dec 8;2(6203):1466-8. doi: 10.1136/bmj.2.6203.1466.
Abstract
A study was conducted to evaluate the effect of indomethacin on orthostatic hypotension in Parkinsonism. Twelve elderly patients participated and the drug was given in two-ways--as an intravenous infusion of 50 mg over 30 minutes and by mouth 50 mg thrice daily for six days. Results were assessed by measuring the degree of hypotension on standing, response to the cold pressor test, and forearm blood flow (by strain-gauge plethysmography). Indomethacin significantly reduced the fall in blood pressure on standing (P less than 0:001) and lessened or reversed orthostatic symptoms. Furthermore, there was an enhanced response to the cold pressor test and a reduction in forearm blood flow. These findings suggest that indomethacin has a positive effect on systemic vascular resistance.
摘要
一项研究旨在评估吲哚美辛对帕金森病体位性低血压的影响。12名老年患者参与了该研究，药物通过两种方式给药——静脉输注50毫克，持续30分钟，以及口服，每日三次，每次50毫克，共六天。通过测量站立时的低血压程度、对冷加压试验的反应以及前臂血流量（通过应变计体积描记法）来评估结果。吲哚美辛显著降低了站立时的血压下降（P小于0.001），并减轻或逆转了体位性症状。此外，对冷加压试验的反应增强，前臂血流量减少。这些发现表明吲哚美辛对全身血管阻力有积极作用。
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