Bettelheim R, Penman H G, Thornton-Jones H, Neville A M
Br J Cancer. 1984 Dec;50(6):771-7. doi: 10.1038/bjc.1984.255.
A prospective study of 232 patients with primary invasive breast cancer (UICC Stages I, II and III) and histologically confirmed axillary node status was carried out to assess the prognostic significance of several readily available clinical and pathological characteristics. In addition to the recognised utility of tumour size and axillary lymph node status, the presence or absence of cohesive clumps of malignant cells in peritumoral vascular spaces (both lymphatic and blood vessels) was found to be prognostically important.
对232例原发性浸润性乳腺癌(国际抗癌联盟I、II和III期)且腋窝淋巴结状态经组织学确认的患者进行了一项前瞻性研究,以评估几种易于获得的临床和病理特征的预后意义。除了肿瘤大小和腋窝淋巴结状态已公认的效用外,还发现肿瘤周围血管间隙(包括淋巴管和血管)中是否存在恶性细胞凝聚团具有预后重要性。