Fyfe M C, Chahl L A
Br J Exp Pathol. 1984 Dec;65(6):671-6.
Ultrasound at frequencies between 0.75 and 3.0 MHz is widely used in the treatment of musculoskeletal injuries in human and veterinary patients. The mechanisms by which ultrasound affects clinical recovery are, however, incompletely understood. At present no clear rationale has been evolved to guide the selection and use of all the factors comprising the dosage of ultrasound in treatment designed to encourage tissue healing. In the present study applications of ultrasound considered to be therapeutic caused a small but significant increase in vascular permeability in the hindpaw ankles of rats in vivo which was abolished by pre-treatment of the rats with a combination of a histamine H1-receptor antagonist and a serotonin antagonist. Histological sections from rat ankles showed that ultrasound also caused a significant increase in the number of degranulated mast cells above control values. Since mast cells contain histamine, low concentrations of which have been associated with healing, the finding that ultrasound produces mast cell degranulation and evidence of histamine release provides a new direction for investigation of the mechanism of its therapeutic action, and for determination of appropriate regimens of treatment.
频率在0.75至3.0兆赫兹之间的超声波广泛应用于人类和兽医患者的肌肉骨骼损伤治疗。然而，超声波影响临床恢复的机制尚未完全明确。目前，尚未形成明确的理论依据来指导在旨在促进组织愈合的治疗中对构成超声剂量的所有因素的选择和使用。在本研究中，被认为具有治疗作用的超声应用在体内导致大鼠后爪踝关节的血管通透性出现小幅度但显著的增加，而用组胺H1受体拮抗剂和5-羟色胺拮抗剂联合预处理大鼠可消除这种增加。大鼠踝关节的组织学切片显示，超声还导致脱颗粒肥大细胞数量显著高于对照值。由于肥大细胞含有组胺，低浓度组胺与愈合相关，超声产生肥大细胞脱颗粒和组胺释放证据这一发现为研究其治疗作用机制以及确定合适的治疗方案提供了新的方向。
