Waldron H A, Waterhouse J A, Tessema N
Br J Ind Med. 1984 Nov;41(4):437-44. doi: 10.1136/oem.41.4.437.
Between 1936 and 1976, 344 cases of scrotal cancer were registered in the West Midlands Region. There was a considerable increase in the number of registrations after 1955, the figures remaining high until the 1970s since when they appear to be falling towards the low level seen in the early years of registration. By the end of December 1981 250 deaths had occurred. The cause of death was known in 226 cases and of these, 97 (42.9%) were attributed to cancer of the scrotum, 40 (17.7%) to other malignancies, and 89 (39.4%) to other causes, scrotal cancer not being mentioned on the death certificate. The mean age at registration was 59.3 years and at death 66 years. Mean survival was 6.6 years with a five year survival rate of 51%. Survival was shorter in men who presented with palpable lymph nodes and greater in those treated with surgery alone. Occupations were known for all but 28 of the cases and of these, 61.9% had been exposed to mineral oil and a further 7.8% to pitch and tar. Among the occupations with exposure to mineral oil, tool setters and tool fitters accounted for the greatest proportion, 89 men having followed those trades. In 74 cases second primary tumours were registered after the scrotal primary, mostly in the skin and bronchus. There was no relation between the development of second primary tumours and exposure to mineral oil or to pitch and tar.
1936年至1976年间，西米德兰兹地区共登记了344例阴囊癌病例。1955年后登记数量大幅增加，这一数字在20世纪70年代之前一直居高不下，此后似乎降至登记初期的低水平。截至1981年12月底，已发生250例死亡。226例病例的死亡原因已知，其中97例（42.9%）归因于阴囊癌，40例（17.7%）归因于其他恶性肿瘤，89例（39.4%）归因于其他原因，死亡证明上未提及阴囊癌。登记时的平均年龄为59.3岁，死亡时为66岁。平均生存期为6.6年，五年生存率为51%。出现可触及淋巴结的男性生存期较短，仅接受手术治疗的男性生存期较长。除28例病例外，所有病例的职业均已知，其中61.9%曾接触矿物油，另有7.8%接触沥青和焦油。在接触矿物油的职业中，模具工和钳工占比最大，有89人从事这些行业。74例病例在阴囊原发性肿瘤之后登记了第二原发性肿瘤，大多发生在皮肤和支气管。第二原发性肿瘤的发生与接触矿物油或沥青和焦油之间没有关联。
