Fitzgerald B A, Billson F A
Br J Ophthalmol. 1984 Nov;68(11):801-6. doi: 10.1136/bjo.68.11.801.
Abnormalities in visually evoked responses have been used to demonstrate abnormal optic nerve fibre projections in human albinos, who have anomalous nystagmoid movements. Using visually evoked potentials we tested the hypothesis that patients with dissociated vertical deviation (another group with anomalous nystagmoid movements) may have abnormal visual evoked responses similar to those of albinos. Patients with dissociated vertical deviation (both unilateral and alternating), patients with congenital esotropia without dissociated vertical deviation, and normal subjects were investigated. The results showed a very high incidence of abnormal visual evoked responses in patients with dissociated vertical deviation, while recordings from the other groups were normal. As well as suggesting the possibility of abnormalities of optic nerve fibre projections, the visual evoked responses showed a marked increase in latency in all patients with dissociated vertical deviation. These results occurred regardless of the visual acuity or amblyopia of the eyes tested. The possible existence of abnormal pathway projection in the presence of dissociated vertical deviation is discussed.
视觉诱发电位异常已被用于证明患有异常眼球震颤运动的人类白化病患者存在视神经纤维投射异常。我们使用视觉诱发电位来检验以下假设：分离性垂直偏斜患者（另一组有异常眼球震颤运动的患者）可能具有与白化病患者相似的异常视觉诱发电位。我们对分离性垂直偏斜患者（包括单侧和交替性）、无分离性垂直偏斜的先天性内斜视患者以及正常受试者进行了研究。结果显示，分离性垂直偏斜患者的视觉诱发电位异常发生率非常高，而其他组的记录均正常。视觉诱发电位不仅提示了视神经纤维投射异常的可能性，还显示所有分离性垂直偏斜患者的潜伏期显著延长。无论所测试眼睛的视力或弱视情况如何，都会出现这些结果。本文讨论了分离性垂直偏斜情况下可能存在的异常通路投射。
