Nelson W H, Khan A, Orr W W, Tamragouri R N
Biol Psychiatry. 1984 Sep;19(9):1293-304.
A group of 277 semiconsecutive psychiatric inpatients manifesting a depressive affect underwent an overnight 1 mg dexamethasone suppression test (DST) and a semistructured diagnostic interview according to DSM-III criteria. For major depressive syndromes (major depression with and without psychosis, bipolar depressed) the sensitivity of the DST was 63.9%, specificity 73.0%, and diagnostic confidence 72.3%. Additionally, a significant interaction between age and baseline cortisol values and nonsuppression rates was found in depressed males but not in nondepressed males nor in depressed and nondepressed females. The authors discuss the implications of these findings.
一组连续收治的277名表现出抑郁情绪的精神科住院患者接受了一次夜间1毫克地塞米松抑制试验（DST），并根据《精神疾病诊断与统计手册》第三版标准进行了半结构化诊断访谈。对于重度抑郁综合征（伴有或不伴有精神病性症状的重度抑郁症、双相抑郁），DST的敏感性为63.9%，特异性为73.0%，诊断可信度为72.3%。此外，在抑郁男性中发现年龄与基线皮质醇值和未抑制率之间存在显著交互作用，但在非抑郁男性以及抑郁和非抑郁女性中未发现。作者讨论了这些发现的意义。
