Bernstein J P, Chung S Y
J Clin Psychiatry. 1984 Oct;45(10):433-6.
The cortisol suppression index (CSI), a ratio of predexamethasone to postdexamethasone plasma cortisol levels, has been suggested as an alternate approach to the use of the DST in the diagnosis of depression. Forty-eight psychiatric inpatients were prospectively studied to compare the utility of the CSI to results obtained using Carroll's fixed values at 4 p.m. and 11 p.m. Eighty-eight percent (22/25) of depressed patients had an 8 a.m. CSI below 7.0; 73% (16/22) had a 4 p.m. CSI less than 2.5. This compared to a 76% detection rate using Carroll's criteria for nonsuppression. In this study the CSI provided a sensitive and specific interpretation of the dexamethasone suppression test in depression.
皮质醇抑制指数（CSI），即地塞米松给药前与给药后血浆皮质醇水平的比值，已被提议作为使用地塞米松抑制试验（DST）诊断抑郁症的另一种方法。对48名精神科住院患者进行了前瞻性研究，以比较CSI与使用卡罗尔下午4点和晚上11点固定值所获得结果的效用。88%（22/25）的抑郁症患者上午8点的CSI低于7.0；73%（16/22）的患者下午4点的CSI小于2.5。相比之下，使用卡罗尔非抑制标准的检测率为76%。在这项研究中，CSI为抑郁症患者的地塞米松抑制试验提供了敏感且特异的解读。
