Saxby P J, Griffiths R W, Corbishley C M, Briggs J C
Br J Plast Surg. 1984 Oct;37(4):496-500. doi: 10.1016/0007-1226(84)90138-3.
The histological material from 147 patients treated for clinical stage I primary cutaneous malignant melanoma between 1968 and 1972 was reviewed. All patients had a minimum follow up of 10 years. Measurements were made of the thickness of uninvolved dermis (DT) deep to the tumour and the tumour thickness (TT) itself. The ratio of dermal thickness: tumour thickness (DT:TT) was correlated with clinical progress at follow-up and compared as a prognostic index with tumour thickness alone. The ratio DT:TT was found to be a useful prognostic guide, a value of greater than 2.0 proving to be a very favourable sign. It is suggested that this simple ratio should be routinely reported in all cases of primary cutaneous malignant melanoma to provide an additional index with a view to assessing its value as a prognostic guide.
回顾了1968年至1972年间接受治疗的147例临床I期原发性皮肤恶性黑色素瘤患者的组织学资料。所有患者的最短随访时间为10年。测量肿瘤深部未受累真皮的厚度（DT）和肿瘤本身的厚度（TT）。真皮厚度与肿瘤厚度之比（DT:TT）与随访时的临床进展相关，并作为预后指标与单独的肿瘤厚度进行比较。发现DT:TT比值是一个有用的预后指标，大于2.0的值被证明是一个非常有利的迹象。建议在所有原发性皮肤恶性黑色素瘤病例中常规报告这个简单的比值，以提供一个额外的指标，以便评估其作为预后指标的价值。
