Ono T, Nishino H, Fukuda M, Sasaki K, Nishijo H
Brain Res. 1984 Oct 8;311(2):323-32. doi: 10.1016/0006-8993(84)90095-7.
The activity of 190 neurons was recorded from the dorsolateral prefrontal cortex of monkeys during an operant task that consisted of 3 phases: visual discrimination of food and non-food, bar pressing to gain access to the food and ingestion. In area 8, a fairly large proportion of the 49 recorded neurons responded in both the visual discrimination (37%) and motor initiation (35%) phases. Some functional heterogeneity seems evident within area 8 since visual discrimination responses were rostral, visuokinesis was central and motor initiation was in the caudal bank of the arcuate sulcus. Neurons in area 9 responded primarily (37%) during the bar pressing phase and less during the visual discrimination phase. Neurons in area 10 responded variously during most phases of the task--food discrimination, bar pressing, and ingestion. Neurons in the periprincipal sulcal area usually responded in the visual discrimination phase, but some which did not respond to food presented in front of the subject responded to meaningful visual or auditory cues that were related to food reward. The data suggest that neurons in the dorsolateral prefrontal cortex have multiple functions related to all phases of complex, learned feeding behavior. Functional roles of the prefrontal cortex and the lateral hypothalamus in development of feeding behavior are discussed.
在一项由三个阶段组成的操作性任务中，记录了猴子背外侧前额叶皮层中190个神经元的活动：食物与非食物的视觉辨别、按压杠杆获取食物以及进食。在8区，所记录的49个神经元中，有相当大比例的神经元在视觉辨别阶段（37%）和运动起始阶段（35%）均有反应。8区内似乎存在明显的功能异质性，因为视觉辨别反应位于嘴侧，视觉运动位于中央，而运动起始位于弓形沟尾侧缘。9区的神经元主要在按压杠杆阶段做出反应（37%）而在视觉辨别阶段反应较少。10区的神经元在任务的大多数阶段——食物辨别、按压杠杆和进食过程中反应各异。主沟周围区域的神经元通常在视觉辨别阶段做出反应，但一些对呈现在实验对象面前的食物无反应的神经元，对与食物奖励相关的有意义视觉或听觉线索有反应。数据表明，背外侧前额叶皮层中的神经元具有与复杂的、习得性进食行为所有阶段相关的多种功能。讨论了前额叶皮层和外侧下丘脑在进食行为发展中的功能作用。
