Ihara T, Ohama K, Satoh H, Fujii T, Nomura K, Fujiwara A
Cancer. 1984 Dec 15;54(12):2988-94. doi: 10.1002/1097-0142(19841215)54:12<2988::aid-cncr2820541229>3.0.co;2-u.
Seven cases of ovarian "pure" immature teratoma were encountered in patients 10 to 38 years of age, six cases being in Stage Ia and one case in Stage IIc. The primary tumors and recurrent growth observed in one case were histologically graded from 0 to 3 according to the criteria of Norris et al. Karyotypes of the tumors and the patients were determined using culture and banding techniques. The only nonsurviving case was in Stage IIc. Four primary tumors belonging to grades 0, 1, and 2 showed a normal 46,XX female karyotype and the patients are alive and healthy. Three grade 3 tumors showed various types of karyotype abnormalities (48,XX,+14,+21; 47,XX,+20; 47,XXX). One patient died, one is alive after experiencing a recurrent tumor, and one has only been followed for 22 months. All seven patients had a normal 46,XX female chromosome constitution. Evidence to date indicates that karyotype of ovarian immature teratoma is either normal female 46,XX or a slight deviation from normal. It is postulated that in ovarian immature teratoma normal 46,XX karyotype is an indicator of favorable prognosis, whereas deviations in karyotype suggest a possibility of poor prognosis.
我们遇到了7例年龄在10至38岁之间的卵巢“纯”未成熟畸胎瘤患者，其中6例处于Ia期，1例处于IIc期。根据诺里斯等人的标准，对1例患者观察到的原发性肿瘤和复发肿瘤进行了组织学分级，从0级到3级。使用培养和显带技术确定了肿瘤和患者的核型。唯一一例死亡的患者处于IIc期。4例0级、1级和2级的原发性肿瘤显示正常的46,XX女性核型，患者存活且健康。3例3级肿瘤显示出各种类型的核型异常（48,XX,+14,+21；47,XX,+20；47,XXX）。1例患者死亡，1例在经历复发肿瘤后存活，1例仅随访了22个月。所有7例患者均具有正常的46,XX女性染色体组成。迄今为止的证据表明，卵巢未成熟畸胎瘤的核型要么是正常女性46,XX，要么是与正常略有偏差。据推测，在卵巢未成熟畸胎瘤中，正常的46,XX核型是预后良好的指标，而核型偏差则提示预后不良的可能性。
