Gibas Z, Talerman A, Faruqi S, Carlson J, Noumoff J
Department of Pathology and Cell Biology, Thomas Jefferson University School of Medicine, Philadelphia, Pennsylvania.
Int J Gynecol Pathol. 1993 Jul;12(3):276-80. doi: 10.1097/00004347-199307000-00013.
We report a case of an immature teratoma of the ovary, grade 3, in which cytogenetic studies were performed on the primary tumor at diagnosis and on a metastasis resected 1 year after removal of the primary tumor. The patient was treated with cisplatin, bleomycin, and etoposide (VP-16) combination chemotherapy. The metastatic tumor was composed of mature teratoma with only small foci of immature tissue. Despite the different histologic appearance of the primary tumor and the metastasis, there was no detectable difference in karyotype between the primary and metastatic tumors. Both showed a pseudodicentric chromosome derived from chromosome 1 and monosomy for chromosome 4. Flow cytometry analysis of the metastatic tumor showed a diploid DNA content, in agreement with the cytogenetic findings. From this case it would appear that chemotherapy-induced maturation of metastatic immature ovarian teratoma is not associated with regression of the malignant karyotype or selection of a karyotypically distinct population of tumor cells.
我们报告一例3级卵巢未成熟畸胎瘤病例，对诊断时的原发肿瘤以及原发肿瘤切除1年后切除的转移灶进行了细胞遗传学研究。患者接受了顺铂、博来霉素和依托泊苷（VP - 16）联合化疗。转移瘤由成熟畸胎瘤组成，仅伴有少量未成熟组织灶。尽管原发肿瘤和转移瘤的组织学表现不同，但原发肿瘤和转移瘤的核型没有可检测到的差异。两者均显示一条源自1号染色体的假双着丝粒染色体和4号染色体单体。转移瘤的流式细胞术分析显示DNA含量为二倍体，与细胞遗传学结果一致。从该病例看来，化疗诱导的转移性未成熟卵巢畸胎瘤成熟与恶性核型的消退或核型不同的肿瘤细胞群体的选择无关。
