双（2-氧代丙基）亚硝胺对斯普拉格-道利大鼠的致癌作用。
The carcinogenic effect of bis-(2-oxopropyl)-nitrosamine on Sprague-Dawley rats.
作者信息
Ketkar M B, Preussmann R, Mohr U
出版信息
Cancer Lett. 1984 Aug;24(1):73-9. doi: 10.1016/0304-3835(84)90082-x.
PMID:6498802
Abstract
Sprague-Dawley rats received subcutaneous injections of bis-2-oxopropyl)-nitrosamine (BOPN) once weekly for life. The animals developed mainly papillomas and squamous cell carcinomas of the nasal cavity, follicle cell carcinomas of the thyroid gland and papillomas and transitional cell carcinomas of renal pelvis, ureter and urinary bladder. The tumour incidence was 100% in all the 3 treated groups. Survival time, tumour latency and multiplicity showed dose dependency.
摘要
斯普拉格-道利大鼠终生每周皮下注射一次双（2-氧代丙基）-亚硝胺（BOPN）。这些动物主要发生鼻腔乳头状瘤和鳞状细胞癌、甲状腺滤泡细胞癌以及肾盂、输尿管和膀胱的乳头状瘤和移行细胞癌。所有3个治疗组的肿瘤发生率均为100%。生存时间、肿瘤潜伏期和肿瘤数量呈现剂量依赖性。
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