慢性皮下注射2,6-二甲基亚硝基吗啉对斯普拉格-道利大鼠的致癌作用。
Carcinogenic effect of chronic subcutaneous injections of 2,6-dimethylnitrosomorpholine in Sprague-Dawley rats.
作者信息
Ovelar M Y, Cardesa A, Mohr U
出版信息
Cancer Lett. 1981 Jul;13(2):159-63. doi: 10.1016/0304-3835(81)90143-9.
PMID:7306953
Abstract
Sprague-Dawley rats received subcutaneous injections of 2,6-dimethylnitrosomorpholine (2,6-DMNM) at 3 different dose levels (1/5, 1/10 or 1/20 LD50) once weekly for life. Up to a 100% rate of tumors of the esophagus was detected in animals which received 1/10 and 1/20 LD50. In addition to tumors of this organ, neoplasms developed at different rates in the lungs and in the liver.
摘要
斯普拉格-道利大鼠终身每周皮下注射一次三种不同剂量水平（1/5、1/10或1/20半数致死量）的2,6-二甲基亚硝基吗啉（2,6-DMNM）。在接受1/10和1/20半数致死量的动物中，检测到高达100%的食管癌发生率。除了该器官的肿瘤外，肺和肝脏中也以不同速率发生肿瘤。
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