Carcinogenic effect of chronic subcutaneous injections of 2,6-dimethylnitrosomorpholine in Sprague-Dawley rats.
作者信息
Ovelar M Y, Cardesa A, Mohr U
出版信息
Cancer Lett. 1981 Jul;13(2):159-63. doi: 10.1016/0304-3835(81)90143-9.
PMID:7306953
Abstract
Sprague-Dawley rats received subcutaneous injections of 2,6-dimethylnitrosomorpholine (2,6-DMNM) at 3 different dose levels (1/5, 1/10 or 1/20 LD50) once weekly for life. Up to a 100% rate of tumors of the esophagus was detected in animals which received 1/10 and 1/20 LD50. In addition to tumors of this organ, neoplasms developed at different rates in the lungs and in the liver.
摘要
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