Ponomarkov V, Cabral J R, Wahrendorf J, Galendo D
Cancer Lett. 1984 Aug;24(1):95-101. doi: 10.1016/0304-3835(84)90085-5.
Styrene-7,8-oxide (200 mg/kg body wt) was given orally to female BDIV rats on 17th day of pregnancy. Their offspring received 96 weekly doses of styrene oxide (100-150 mg/kg body wt). Following the continuous administration of styrene oxide, an increased incidence, statistically significant, of forestomach tumours was observed in rats of both sexes. The incidence of tumours occurring at other sites was similar in treated and control animals. The present results show that styrene oxide is a direct-acting carcinogen producing benign and malignant tumours of the forestomach.
在妊娠第17天，给雌性BDIV大鼠口服苯乙烯 - 7,8 - 氧化物（200毫克/千克体重）。它们的后代接受96次每周剂量的氧化苯乙烯（100 - 150毫克/千克体重）。连续给予氧化苯乙烯后，在雌雄大鼠中均观察到前胃肿瘤的发生率增加，具有统计学意义。在治疗组和对照组动物中，其他部位发生肿瘤的发生率相似。目前的结果表明，氧化苯乙烯是一种直接作用的致癌物，可导致前胃产生良性和恶性肿瘤。
