接触苯乙烯的工人血液中的苯乙烯-7,8-氧化物。
Styrene-7,8-oxide in blood of workers exposed to styrene.
作者信息
Korn M, Gfrörer W, Filser J G, Kessler W
机构信息
Institut für Arbeits- und Sozialmedizin, Tübingen, Germany.
出版信息
Arch Toxicol. 1994;68(8):524-7. doi: 10.1007/s002040050107.
A field study was carried out on 13 workers exposed to styrene vapors at time-weighted average concentrations between 10 and 73 ppm. The reactive intermediate styrene-7,8-oxide was determined in blood samples using a direct gas chromatographic method. Styrene-7,8-oxide concentrations were in the range between 0.9 and 4.1 micrograms/l blood. Linear correlations were found between styrene-7,8-oxide in blood and styrene in ambient air and blood. For an exposure concentration of 20 ppm styrene (German MAK value) a steady-state level of about 1 microgram styrene-7,8-oxide/l blood was calculated.
对13名接触苯乙烯蒸气的工人进行了一项现场研究，其时间加权平均浓度在10至73 ppm之间。采用直接气相色谱法测定血样中的反应性中间体苯乙烯-7,8-氧化物。苯乙烯-7,8-氧化物浓度在0.9至4.1微克/升血液范围内。发现血液中的苯乙烯-7,8-氧化物与环境空气中的苯乙烯以及血液中的苯乙烯之间存在线性相关性。对于20 ppm苯乙烯的暴露浓度（德国职业接触限值），计算出血液中苯乙烯-7,8-氧化物的稳态水平约为1微克/升。
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