Williams G M, Numoto S
Carcinogenesis. 1984 Dec;5(12):1689-96. doi: 10.1093/carcin/5.12.1689.
The organochlorine pesticides chlordane and heptachlor were demonstrated to be liver neoplasm promoters in mice. Male B6C3F1 mice exposed to diethylnitrosamine (DEN) for 14 weeks followed by 25 weeks on control diet developed a 40% incidence of liver neoplasms whereas those given chlordane or heptachlor afterwards had approximately an 80% incidence of liver neoplasms, as did mice given DDT, a positive reference compound. Mice exposed to DEN also developed neoplasms of the forestomach and lung, but the incidences of these were not increased by chlordane, heptachlor or any other exposure. None of the chemicals given alone for the last 25 weeks of the study increased the incidence of liver neoplasms and none given before DEN produced a syncarcinogenic effect.
有机氯农药氯丹和七氯被证明是小鼠肝脏肿瘤的促进剂。雄性B6C3F1小鼠暴露于二乙基亚硝胺（DEN）14周，随后在对照饮食上喂养25周，肝脏肿瘤的发生率为40%；而之后给予氯丹或七氯的小鼠，肝脏肿瘤的发生率约为80%，给予阳性对照化合物滴滴涕（DDT）的小鼠也是如此。暴露于DEN的小鼠还出现了前胃和肺部肿瘤，但氯丹、七氯或任何其他暴露并未增加这些部位肿瘤的发生率。在研究的最后25周单独给予的任何一种化学物质都没有增加肝脏肿瘤的发生率，在给予DEN之前给予的任何物质也没有产生协同致癌作用。
