Aniansson A, Zetterberg C, Hedberg M, Henriksson K G
Clin Orthop Relat Res. 1984 Dec(191):193-201.
Muscle biopsy material from vastus lateralis musculus quadriceps was obtained during surgery from 43 66-100-year-old female and nine 70-89-year-old male patients with fresh hip fractures. Before the accident, 18 women and two men were clinically healthy, and in the others, one-third had cardiovascular, one-third locomotor, and one-third neurologic disorders. Twelve women lived in institutions. The other women and all of the men lived in their own homes. A striking finding was a more advanced reduction in muscle fiber size in the vastus lateralis, especially in the fast twitch (FT) fibers. The reduction occurred in preaccident clinically healthy fracture patients. With advancing age, the proportions of the slow twitch (ST) and FT fibers remained the same. Well-maintained, enzymatic metabolic capacity, moderate neuropathic changes, and absence of myopathic changes indicate that the quality of the muscle tissue is relatively well preserved, even in elderly patients with hip fractures. Muscle fiber atrophy and weakness in muscle strength may be attributable in part to a low physical activity and are possibly reversible with exercise in some individuals.
在手术过程中，从43名66至100岁的女性和9名70至89岁的男性新鲜髋部骨折患者的股外侧肌获取肌肉活检材料。事故发生前，18名女性和2名男性临床健康，其他患者中，三分之一患有心血管疾病，三分之一患有运动系统疾病，三分之一患有神经系统疾病。12名女性住在养老院。其他女性和所有男性都住在自己家中。一个显著的发现是股外侧肌中肌纤维大小的更明显减小，尤其是在快肌纤维中。这种减小发生在事故前临床健康的骨折患者中。随着年龄的增长，慢肌纤维和快肌纤维的比例保持不变。良好的酶代谢能力、中度的神经病变以及无肌病改变表明，即使在老年髋部骨折患者中，肌肉组织的质量也相对保存良好。肌纤维萎缩和肌肉力量减弱可能部分归因于体力活动不足，并且在某些个体中通过锻炼可能是可逆的。
