Kjaeldgaard A, Larsson B
Contraception. 1984 Aug;30(2):169-78. doi: 10.1016/0010-7824(84)90101-x.
The separate effect of ethinylestradiol (4 micrograms/kg b.w./day) and d-norgestrel (20 micrograms/kg b.w./day) on the fibrinolytic activity in plasma and in vessel walls of the hind leg was investigated in an experimental study on rats. No hormonal effect on the fibrinolytic activity in plasma was registered. However, a significantly increased fibrinolytic activity in the vessel wall of the distal hind leg was demonstrated in the d-norgestrel-treated rats with plasma levels well below those reported in women using combined contraceptive pills. On the contrary, the fibrinolytic activity of the vessel wall was uninfluenced in the ethinylestradiol-treated rats with plasma levels corresponding to those in women on contraceptive pills containing 30 micrograms ethinylestradiol.
在一项对大鼠的实验研究中，研究了乙炔雌二醇（4微克/千克体重/天）和炔诺孕酮（20微克/千克体重/天）对血浆和后腿血管壁纤维蛋白溶解活性的单独作用。未发现激素对血浆纤维蛋白溶解活性有影响。然而，在血浆水平远低于使用复方避孕药的女性所报告水平的炔诺孕酮治疗的大鼠中，后肢远端血管壁的纤维蛋白溶解活性显著增加。相反，在血浆水平与服用含30微克乙炔雌二醇避孕药的女性相当的乙炔雌二醇治疗的大鼠中，血管壁的纤维蛋白溶解活性未受影响。
