Cnattingius S, Axelsson O, Eklund G, Lindmark G, Meirik O
Early Hum Dev. 1984 Sep;10(1-2):45-55. doi: 10.1016/0378-3782(84)90110-5.
In a prospective clinical study from an unselected, area-based population, the influence on birthweight for gestational age of different factors was studied, with special respect to 15 risk factors for intrauterine growth retardation (IUGR) recognizable in early pregnancy. In the multiple regression analyses performed, birthweight for gestational age was used as the dependent variable. Only 10% of the variance in birthweight for gestational age could be explained. A correlation was found between the number of risk factors and birthweight for gestational age. Four risk factors had a significant negative influence on birthweight for gestational age: smoking, previous birth of a low birthweight infant, a low prepregnancy weight and addiction. No single risk factor influenced birthweight for gestational age as much as parity. When a risk factor was present the expected increase in birthweight for gestational age with increasing parity did not appear.
在一项针对未经过选择的、基于地区的人群的前瞻性临床研究中，研究了不同因素对孕周出生体重的影响，特别关注了在孕早期可识别的15种宫内生长受限（IUGR）风险因素。在进行的多元回归分析中，孕周出生体重被用作因变量。孕周出生体重的变异中只有10%能够得到解释。发现风险因素的数量与孕周出生体重之间存在相关性。四个风险因素对孕周出生体重有显著的负面影响：吸烟、既往有低出生体重婴儿出生、孕前体重低和成瘾。没有单一风险因素对孕周出生体重的影响能与产次相媲美。当存在风险因素时，随着产次增加孕周出生体重预期的增加并未出现。
