Tuomilehto J, Salonen J T, Nissinen A
Eur Heart J. 1984 Sep;5(9):739-44. doi: 10.1093/oxfordjournals.eurheartj.a061735.
The prevalence of hypertension in general and of those complications associated with isolated systolic hypertension (at least 165 mmHg systolic and less than 95 mmHg diastolic pressure) were assessed in a random sample of 3888 men and 4336 women aged 30-59 years at the beginning of the study. The prevalence of isolated systolic hypertension was about 5% both in men and women aged 30 to 49 years; in those aged 50 to 59 years the prevalence was 7% in men and 13% in women. Systolic hypertension was associated with an increased risk of acute myocardial infarction (AMI), cerebrovascular stroke and death both in men and women in the seven-year follow-up period. The relative risk of AMI in men and women with isolated systolic hypertension was 1.65 (P less than 0.05) and 0.87, respectively, and the relative risk of stroke 0.57 and 1.29, respectively. Isolated systolic hypertension is not uncommon in the middle-aged population and its impact on cardiovascular complications seems to be significant not only on the elderly but also in the middle-aged.
在研究开始时，对年龄在30至59岁之间的3888名男性和4336名女性的随机样本进行了总体高血压患病率以及与单纯收缩期高血压相关的并发症（收缩压至少165 mmHg且舒张压低于95 mmHg）患病率的评估。在30至49岁的男性和女性中，单纯收缩期高血压的患病率约为5%；在50至59岁的人群中，男性患病率为7%，女性患病率为13%。在七年的随访期内，收缩期高血压与男性和女性急性心肌梗死（AMI）、脑血管卒中和死亡风险的增加相关。单纯收缩期高血压男性和女性发生AMI的相对风险分别为1.65（P<0.05）和0.87，中风的相对风险分别为0.57和1.29。单纯收缩期高血压在中年人群中并不罕见，其对心血管并发症的影响似乎不仅对老年人，而且对中年人也很显著。
