Singhal A, Bali A, Jain R K, Gupta C M
FEBS Lett. 1984 Dec 3;178(1):109-13. doi: 10.1016/0014-5793(84)81251-x.
Incorporation of tuftsin derivatives, Thr-Lys-Pro-Arg-NH-C18H37 or Thr-Lys-Pro-Arg-NH-(CH2)2-NH-COC15H31, into an egg phosphatidylcholine/cholesterol liposome bilayer led to significantly enhanced binding of the liposomes to PMN leukocytes at 37 degrees C but not at 0 degree C. Under identical conditions, no such enhanced binding of the liposomes was observed with erythrocytes and lymphocytes. These results demonstrate that grafting of tuftsin on the liposome bilayer enables the liposome to recognize specifically the PMN leukocytes and to deliver its contents to these cells.
将促吞噬素衍生物苏氨酰-赖氨酰-脯氨酰-精氨酰-NH-C₁₈H₃₇或苏氨酰-赖氨酰-脯氨酰-精氨酰-NH-(CH₂)₂-NH-COC₁₅H₃₁掺入鸡蛋磷脂酰胆碱/胆固醇脂质体双层中，导致脂质体在37℃时与中性粒细胞的结合显著增强，但在0℃时没有这种增强。在相同条件下，红细胞和淋巴细胞未观察到脂质体的这种增强结合。这些结果表明，促吞噬素接枝到脂质体双层上能够使脂质体特异性识别中性粒细胞并将其内容物递送至这些细胞。
