Gupta C M, Puri A, Jain R K, Bali A, Anand N
FEBS Lett. 1986 Sep 15;205(2):351-4. doi: 10.1016/0014-5793(86)80927-9.
In Plasmodium berghei infections, the mortality rate and parasitaemias were significantly reduced and the mean survival time was considerably enhanced by pretreating the animals with a tuftsin derivative, Thr-Lys-Pro-ARg-NH-(CH2)2-NHCOC15H31. This effect of the modified tuftsin was further increased upon its incorporation in the liposome bilayer. These results indicate that tuftsin and its derivatives may prove useful in enhancing nonspecific host resistance against protozoan infections.
在伯氏疟原虫感染中，用一种缩氨酸衍生物苏肽生（Thr-Lys-Pro-Arg-NH-(CH2)2-NHCOC15H31）预处理动物后，死亡率和疟原虫血症显著降低，平均存活时间大幅延长。将这种修饰后的苏肽生掺入脂质体双层后，其效果进一步增强。这些结果表明，苏肽生及其衍生物可能在增强宿主对原生动物感染的非特异性抵抗力方面发挥作用。
