Nowicki M J, Tong M J, Nair P V, Stevenson D
Hepatology. 1984 Nov-Dec;4(6):1129-33. doi: 10.1002/hep.1840040606.
The effect of a short course of prednisone therapy on serum IgM type antibody to the hepatitis B core antigen (anti-HBc IgM) was studied in 14 male patients with chronic active type B hepatitis. Eleven patients (78.5%) became positive for serum anti-HBc IgM either during or shortly after prednisone withdrawal. Detection of anti-HBc IgM correlated with an increase in hepatitis B virus specific DNA-polymerase activity and was followed by a rise in serum transaminase levels. Six patients with histologic evidence of cirrhosis developed anti-HBc IgM which lasted six or more months after prednisone therapy and had a rapid onset of hepatic decompensation manifested by encephalopathy with ascites and/or variceal bleeding. In 17 untreated chronic active type B hepatitis patients who served as controls, anti-HBc IgM was detected at low levels in only a single serum sample from each of two patients during the same observation period.
对14例慢性活动性乙型肝炎男性患者研究了短期泼尼松治疗对血清乙型肝炎核心抗原IgM型抗体（抗-HBc IgM）的影响。11例患者（78.5%）在泼尼松撤药期间或撤药后不久血清抗-HBc IgM转为阳性。抗-HBc IgM的检测与乙型肝炎病毒特异性DNA聚合酶活性增加相关，并随后血清转氨酶水平升高。6例有肝硬化组织学证据的患者出现抗-HBc IgM，在泼尼松治疗后持续6个月或更长时间，并迅速出现肝失代偿，表现为伴有腹水和/或静脉曲张出血的脑病。在作为对照的17例未经治疗的慢性活动性乙型肝炎患者中，在同一观察期内，仅在两名患者各自的一份血清样本中检测到低水平的抗-HBc IgM。
