Karkinen-Jääskeläinen M
J Embryol Exp Morphol. 1978 Apr;44:167-79.
The interactive events leading to lens formation and the developmental potentialities of the presumptive lens ectoderm were examined in vitro. The presumptive lens ectoderm of both mouse and chick embryos was capable of forming a lens even when isolated from the optic vesicle before the two tissues reach the stage of close association. This lens-forming bias can be released with favourable culture conditions and by various heterotypic mesenchymes. The same permissive, unspecific conditions or heterotypic tissues failed to trigger lens formation in trunk ectoderm. The directive effect of the optic vesicle was demonstrated in experiments where it was grown in contact with the trunk ectoderm. The latter developed distinct lentoid bodies synthesizing lens proteins. The origin of the lentoid was confirmed in interspecies combination of chick and quail tissues. It is concluded that lens formation is governed by a series of interactive events consisting of both directive and permissive influences.
在体外研究了导致晶状体形成的相互作用事件以及假定晶状体外胚层的发育潜能。即使在小鼠和鸡胚胎的假定晶状体外胚层与视泡在两个组织达到紧密关联阶段之前分离，它也能够形成晶状体。这种晶状体形成倾向可以通过有利的培养条件和各种异型间充质来解除。相同的允许性、非特异性条件或异型组织未能触发躯干外胚层形成晶状体。视泡的定向作用在其与躯干外胚层接触生长的实验中得到了证明。后者发育出合成晶状体蛋白的明显类晶状体。在鸡和鹌鹑组织的种间组合中证实了类晶状体的起源。得出的结论是，晶状体形成受一系列由定向和允许影响组成的相互作用事件支配。
