Cunha G R, Shannon J M, Neubauer B L, Sawyer L M, Fujii H, Taguchi O, Chung L W
Hum Genet. 1981;58(1):68-77. doi: 10.1007/BF00284152.
Development of male and female accessory sexual glands is described in terms of the respective roles of epithelium and mesenchyme. During embryonic and neonatal periods mesenchyme alone exhibits androgen receptor activity (nuclear androgen binding sites) and is the actual target and mediator of the morphogenetic effects of androgens upon the epithelium. Mesenchyme induces specific patterns of epithelial morphogenesis, cytodifferentiation, and probably also specifies the functional (biochemical) activities of the epithelium. Mesenchymal influence upon expression of epithelial characteristics occurs in the perinatal period during morphogenesis, but also plays an important role in adulthood by maintaining favorable conditions for maintenance of epithelial morphology and function. Morphogenetic processes in adult hormone-dependent organs are though to be mediated by stromal cells.
男性和女性附属性腺的发育是根据上皮组织和间充质各自的作用来描述的。在胚胎期和新生儿期，只有间充质表现出雄激素受体活性（核雄激素结合位点），并且是雄激素对上皮组织形态发生作用的实际靶标和介质。间充质诱导上皮形态发生、细胞分化的特定模式，并且可能还决定了上皮组织的功能（生化）活性。间充质对上皮特征表达的影响发生在围产期形态发生期间，但在成年期通过维持上皮形态和功能的有利条件也起着重要作用。成体激素依赖性器官中的形态发生过程被认为是由基质细胞介导的。
