Hashimoto T, Marks R
J Invest Dermatol. 1984 Dec;83(6):441-4. doi: 10.1111/1523-1747.ep12273546.
The effect of a factor XIII preparation on active epidermal cell migration in vitro has been studied using both floating and attached types of human skin explants in short-term maintenance cultures. In both types of experiment the factor XIII preparation proved to have an inhibitory effect on epidermal cell migration in a dose-dependent fashion. This effect was shown to be independent of both the presence of fibrin and the concentration of calcium ion in the medium. The preparation also showed inhibition of the proliferation of epidermal cells in cell culture.
利用人皮肤外植体的漂浮型和贴壁型在短期维持培养中，研究了凝血因子 XIII 制剂对体外活性表皮细胞迁移的影响。在这两种类型的实验中，凝血因子 XIII 制剂均被证明对表皮细胞迁移具有剂量依赖性抑制作用。结果表明，这种作用与纤维蛋白的存在和培养基中钙离子的浓度均无关。该制剂在细胞培养中也显示出对表皮细胞增殖的抑制作用。
