Factor XIII inhibits epidermal cell migration in vitro.

The effect of a factor XIII preparation on active epidermal cell migration in vitro has been studied using both floating and attached types of human skin explants in short-term maintenance cultures. In both types of experiment the factor XIII preparation proved to have an inhibitory effect on epidermal cell migration in a dose-dependent fashion. This effect was shown to be independent of both the presence of fibrin and the concentration of calcium ion in the medium. The preparation also showed inhibition of the proliferation of epidermal cells in cell culture.