Chuong C M, Chen H M
Department of Pathology, School of Medicine, University of Southern California, Los Angeles 90033.
Am J Pathol. 1991 Feb;138(2):427-40.
Both neural cell adhesion molecules (N-CAM) and tenascin (cytotactin) are important in embryonic morphogenesis but their expression is reduced greatly in adults. This study examined whether they are induced during wound healing. The spatial and temporal expression patterns of these two and other adhesion molecules in the healing of skin, cartilage, and tendon were compared. Neural cell adhesion molecules, tenascin, and fibronectin are induced in the granulation tissue but the order of prevalence is fibronectin, tenascin, N-CAM. The order of appearance is N-CAM and fibronectin, and then tenascin. The order of disappearance is N-CAM, tenascin, fibronectin. Liver cell adhesion molecules are present in the epidermis undergoing re-epithelization. Explant cultures showed that N-CAM and tenascin are synthesized by wound fibroblasts. These results suggest that N-CAM and tenascin, widely used in embryonic morphogenesis, are induced in a variety of connective tissues during wound healing.
神经细胞黏附分子（N-CAM）和腱生蛋白（细胞趋化蛋白）在胚胎形态发生过程中都很重要，但它们在成体中的表达大幅降低。本研究检测了它们在伤口愈合过程中是否会被诱导产生。比较了这两种黏附分子以及其他黏附分子在皮肤、软骨和肌腱愈合过程中的时空表达模式。神经细胞黏附分子、腱生蛋白和纤连蛋白在肉芽组织中被诱导产生，但出现的先后顺序是纤连蛋白、腱生蛋白、N-CAM。出现顺序是N-CAM和纤连蛋白，然后是腱生蛋白。消失顺序是N-CAM、腱生蛋白、纤连蛋白。肝细胞黏附分子存在于正在进行重新上皮化的表皮中。外植体培养显示，N-CAM和腱生蛋白由伤口成纤维细胞合成。这些结果表明，广泛用于胚胎形态发生的N-CAM和腱生蛋白在伤口愈合过程中会在多种结缔组织中被诱导产生。
