MacEwen E G, Hayes A A, Mooney S, Patnaik A K, Harvey H J, Passe S, Hardy W D
J Biol Response Mod. 1984 Oct;3(5):541-6.
Seventy-three cats with untreated malignant mammary tumors (64 with adenocarcinoma, 9 with carcinoma in situ) were selected for study. All cats were clinically staged and stratified on the basis of tumor volume. Following radical mastectomy, the cats were randomized for treatment with either levamisole or placebo. There was no significant difference in either survival time or recurrence rate between the levamisole and placebo groups. The most significant prognostic factor was tumor volume: Cats with small tumors had a significantly enhanced survival time (p = 0.00006) and lower recurrence rate (p = 0.00004). Breed of cat was also an important prognostic factor; the domestic short-haired cats had a significantly (p = 0.038) longer survival time than the cats of other breeds.
选取73只患有未经治疗的恶性乳腺肿瘤的猫（64只腺癌，9只原位癌）进行研究。所有猫均根据肿瘤体积进行临床分期和分层。根治性乳房切除术后，将猫随机分为左旋咪唑治疗组或安慰剂组。左旋咪唑组和安慰剂组在生存时间或复发率上均无显著差异。最显著的预后因素是肿瘤体积：肿瘤较小的猫生存时间显著延长（p = 0.00006），复发率较低（p = 0.00004）。猫的品种也是一个重要的预后因素；家养短毛猫的生存时间显著长于其他品种的猫（p = 0.038）。
