Landgren S, Bäckström T, Kalistratov G
J Neurol Sci. 1978 Mar;36(1):119-33. doi: 10.1016/0022-510x(78)90166-1.
The effect of intravenous infusion of progesterone and Mebumal (ACO, Sweden; penotobarbital, INN) on the frequency and amplitude of the spontaneous interictal spikes from a penicillin focus in the cerebral cortex was investigated in ovariectomized cats anaesthetized with chloralose. The plasma concentration of progesterone was determined. It was found that the generation of penicillin spikes was depressed by progesterone in plasma concentrations as low as 40 ng/ml. Equimolar doses of Mebumal were less effective.
在用氯醛糖麻醉的去卵巢猫中，研究了静脉输注孕酮和美布比妥（瑞典ACO公司生产；异戊巴比妥，国际非专利药品名称）对大脑皮层青霉素病灶自发发作间期棘波频率和幅度的影响。测定了血浆孕酮浓度。发现血浆中孕酮浓度低至40纳克/毫升时就能抑制青霉素棘波的产生。等摩尔剂量的美布比妥效果较差。
