Herzog Andrew G
Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Wellesley, Massachusetts 02481, USA.
Neurotherapeutics. 2009 Apr;6(2):383-91. doi: 10.1016/j.nurt.2009.01.009.
Seizures do not occur randomly in the majority of people with epilepsy. They tend to cluster. Seizure clusters, in turn, commonly occur with a temporal rhythmicity that shows a readily identifiable and predictable periodicity. When the periodicity of seizure exacerbation in women conforms to that of the menstrual cycle, it is commonly known as catamenial epilepsy. This may be attributable to 1) the neuroactive properties of steroid hormones and 2) the cyclic variation in their serum levels. If hormones play a role in seizure occurrence, hormones may also have a role in treatment. Progesterone has potent GABAergic metabolites that may provide safe and effective seizure control in women who have catamenial epilepsy.
在大多数癫痫患者中，癫痫发作并非随机发生。它们往往会成簇出现。反过来，癫痫发作簇通常会按照一种时间节律发生，这种节律显示出易于识别和预测的周期性。当女性癫痫发作加剧的周期与月经周期一致时，通常被称为经期癫痫。这可能归因于1）甾体激素的神经活性特性和2）其血清水平的周期性变化。如果激素在癫痫发作中起作用，那么激素在治疗中可能也发挥作用。孕酮具有强大的γ-氨基丁酸能代谢产物，这可能为患有经期癫痫的女性提供安全有效的癫痫控制。
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