液晶作为一种潜在的软膏载体。
Liquid crystals as a potential ointment vehicle.
作者信息
Wahlgren S, Lindstrom A L, Friberg S E
出版信息
J Pharm Sci. 1984 Oct;73(10):1484-6. doi: 10.1002/jps.2600731042.
PMID:6502503
Abstract
A lecithin-water lyotropic liquid crystal was used as an ointment vehicle for a hydrocortisone formulation. The hydrocortisone was soluble in the liquid crystalline phase up to 5% by weight. The diffusion coefficient determined for the hydrocortisone in the liquid crystalline phase was 5.5 X 10(-9) cm X s-1, which is four magnitudes higher than the corresponding value for skin.
摘要
一种卵磷脂 - 水溶致液晶被用作氢化可的松制剂的软膏基质。氢化可的松在液晶相中重量溶解度可达5%。所测定的氢化可的松在液晶相中的扩散系数为5.5×10⁻⁹ cm·s⁻¹，这比其在皮肤中的相应值高四个数量级。
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