Sosa R E, Muecke E C, Vaughan E D, McCarron J P
J Urol. 1984 Dec;132(6):1097-100. doi: 10.1016/s0022-5347(17)50050-6.
The records of 24 patients with renal cell carcinoma involving the inferior vena cava who were free of metastatic disease at presentation were reviewed retrospectively. The over-all 2-year survival for the group was 45.8 per cent, with a mean survival of 38.9 months. When the group was analyzed according to the level of extension of the vena caval thrombus marked differences in the rate of survival and of incidence of local progression of disease were found. The 10 patients with an infrahepatic vena caval thrombus had a 2-year survival rate of 80 per cent and a mean survival of 61.4 months. Two patients (20 per cent) had extension of tumor into the perinephric fat and none had involvement of the regional lymph nodes. The 14 patients with a vena caval thrombus extending to the level of the hepatic veins or beyond had a 2-year survival rate of 21 per cent and a mean survival of 22.9 months. Tumor was present in the regional lymph nodes and/or perinephric fat in 9 of these patients (64 per cent). These results suggest that the level of vena caval involvement by tumor thrombus in patients with renal cell carcinoma has prognostic significance.
对24例肾细胞癌累及下腔静脉且初诊时无转移疾病的患者记录进行回顾性分析。该组患者的总体2年生存率为45.8%，平均生存期为38.9个月。根据腔静脉血栓的扩展程度对该组患者进行分析时，发现生存率和疾病局部进展发生率存在显著差异。10例肝下腔静脉血栓患者的2年生存率为80%，平均生存期为61.4个月。2例患者（20%）肿瘤扩展至肾周脂肪，无区域淋巴结受累。14例腔静脉血栓扩展至肝静脉水平或更高水平的患者的2年生存率为21%，平均生存期为22.9个月。其中9例患者（64%）区域淋巴结和/或肾周脂肪有肿瘤。这些结果表明，肾细胞癌患者肿瘤血栓累及腔静脉的程度具有预后意义。
