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亚硒酸盐对喂食甲基汞的小鼠器官中无机汞蓄积的影响。

Alteration of inorganic mercury accumulation due to selenite in organs of mice fed methylmercury.

作者信息

Suzuki T, Yamamoto R

出版信息

Sangyo Igaku. 1984 Mar;26(2):125-9.

PMID:6503010
Abstract

Mice were fed methylmercury (10 nmol/g feed) and selenite (0, 8, 20 or 50 nmol/ml drinking water) for one or two weeks. Doses of selenite and duration of feeding were determining factors of total mercury and inorganic mercury concentrations in organs. Increasing the dose of selenite produced the following results: concentration of total mercury increased in the brain and liver and decreased in the blood, kidneys and spleen; concentration of inorganic mercury increased in the liver and spleen, decreased in the kidneys, and remained unchanged in the brain; the rate of inorganic mercury to total mercury increased in the liver and spleen, decreased in the brain, and remained unchanged in the kidneys. In every case, inorganic mercury in the blood was below the detection limit.

摘要

给小鼠喂食甲基汞(每克饲料含10纳摩尔)和亚硒酸盐(饮用水中含量分别为0、8、20或50纳摩尔/毫升),持续一或两周。亚硒酸盐剂量和喂食持续时间是器官中总汞和无机汞浓度的决定因素。增加亚硒酸盐剂量产生了以下结果:大脑和肝脏中的总汞浓度升高,而血液、肾脏和脾脏中的总汞浓度降低;肝脏和脾脏中的无机汞浓度升高,肾脏中的无机汞浓度降低,大脑中的无机汞浓度保持不变;肝脏和脾脏中无机汞与总汞的比率升高,大脑中的该比率降低,肾脏中的该比率保持不变。在每种情况下,血液中的无机汞均低于检测限。

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