McCarron M M, Walberg C B, Soares J R, Gross S J, Baselt R C
J Anal Toxicol. 1984 Sep-Oct;8(5):197-201. doi: 10.1093/jat/8.5.197.
Paired serum and saliva samples, obtained from 100 emergency department patients suspected of phencyclidine (PCP) intoxication, were analyzed using a specific PCP radioimmunoassay (RIA). Seventy-four of the 100 saliva samples and 75 of the paired serum samples were positive for PCP. The final clinical diagnosis was PCP intoxication in 79 cases. Of these, both serum and saliva tests were positive in 70 cases, only serum was positive in two cases, and both serum and saliva samples were negative in seven cases. The concentration of PCP in the samples did not correlate with the severity of PCP intoxication. In the remaining 21 cases, with no clinical evidence of PCP intoxication, PCP assays were negative in both serum and saliva in 17 cases, three patients had positive saliva and serum tests, and one other patient had a positive PCP saliva assay. Thus, saliva would appear to be as reliable as serum as a specimen for PCP analysis.
从100名疑似苯环利定（PCP）中毒的急诊科患者中采集配对的血清和唾液样本，采用特异性PCP放射免疫分析（RIA）进行检测。100份唾液样本中的74份以及配对血清样本中的75份PCP检测呈阳性。最终临床诊断为PCP中毒的有79例。其中，血清和唾液检测均为阳性的有70例，仅血清阳性的有2例，血清和唾液样本均为阴性的有7例。样本中PCP的浓度与PCP中毒的严重程度无关。在其余21例无PCP中毒临床证据的病例中，17例血清和唾液中的PCP检测均为阴性，3例患者的唾液和血清检测呈阳性，另有1例患者的PCP唾液检测呈阳性。因此，唾液作为PCP分析的样本似乎与血清一样可靠。
