Horrobin D F, Huang Y S, Cunnane S C, Manku M S
Lipids. 1984 Oct;19(10):806-11. doi: 10.1007/BF02534476.
Essential fatty acids were estimated in plasma, red blood cells and liver total phospholipids in rats, mice, hamsters, guinea pigs, rabbits and humans. There were large species differences, suggesting that different species levels should be borne in mind when choosing an animal for a particular study. The 2 species most susceptible to atheroma, the guinea pig and the rabbit, had very high levels of linoleic acid and low levels of linoleic acid metabolites. n-3 fatty acid levels were low in guinea pigs and rabbits and the ratio of n-3 to n-6 fatty acids also was low in the rat. Mice and hamsters had the highest n-3 levels, suggesting they may be the best species to use for studies on the roles of n-3 essential fatty acids. Mice and hamsters and, in some respect rats, were closest to humans in their fatty acid patterns.
对大鼠、小鼠、仓鼠、豚鼠、兔子和人类的血浆、红细胞及肝脏总磷脂中的必需脂肪酸进行了评估。存在很大的物种差异，这表明在为特定研究选择动物时应考虑不同的物种水平。最易患动脉粥样硬化的两个物种，豚鼠和兔子，亚油酸水平非常高，而亚油酸代谢物水平较低。豚鼠和兔子的n-3脂肪酸水平较低，大鼠的n-3与n-6脂肪酸比例也较低。小鼠和仓鼠的n-3水平最高，这表明它们可能是用于研究n-3必需脂肪酸作用的最佳物种。在脂肪酸模式方面，小鼠、仓鼠以及在某些方面大鼠与人类最为接近。
